- Immunodeficiency Disorders
X-linked recessive defect in tyrosine kinase gene resulting in failure of B-cell precursors to mature. Symptoms recurrent pyrogenic bacterial infections. Treatment, Pooled gamma globulin.
Common Variable Immunodeficiency
Caused by intrinsic B-cell deficiency. Symptoms' increased incidence of recurrent pyrogenic infections. Treatment; antibodies, IV gamma globulin therapy.
A disorder caused by a defect in chromosome 22, results in the poor development of several body systems. Symptoms can vary in type and severity, but includes recurrent viral, fungal, and protozoal infections, tetany, cardiovascular defects, facial abnormalities. Treatment; fetal thymus transplantation to restore T-cell immunity.
Severe Combined Immunodeficiency Disease
X-linked recessive disorder resulting in a reduced or malfunctioning T and B lymphocytes. Symptoms include; severe, recurrent viral, bacterial, fungal, and protozoal infections, failure to thrive. Treatment: Adonosine deaminase gene transplantation, bone marrow transplantation, stem cell transplantation.
Chronic Granulomatous Disease of Childhood
An inherited disorder in which immune system cells called phagocytes do not function properly. This leads to ongoing and severe infection. Treatment; Gamma interferon, prophylactic antibiotics, gene therapy.
Failure of gamma-interferon production by helper T cells. Symptoms; non inflamed cold recurrent Staphylococcal abscesses, eczema. May also have a characteristic facial appearance, with a broad nose, deep-set eyes with prominent forehead, and generalized coarsening of the facial features with age. Treatment; antibiotics to treat infections.