- Disorders of the Endocrine Pancreas
Type I, insulin deficiency arising from Beta cell destruction in the pancreas, caused by genetic, autoimmune or environmental factors.
Type II mediated by decreased insulin receptors and decreased response to glucose. Caused obesity, diet, lifestyle factors.
Symptoms include; feeling very thirsty, urinating frequently, particularly at night, feeling very tired, weight loss and loss of muscle bulk. Treatment; Diet restrictions,lifestyle changes, insulin replacement for type I, support for associated complications.
Pancreatic islet cell tumor. Symptoms; abdominal pain, diarrhoea, burning, aching, gnawing or discomfort in your upper abdomen, acid reflux and heartburn, nausea and vomiting, weakness, bleeding in your digestive tract, unintended weight loss, decreased appetite, anaemia. Treatment; removal of gastrinoma, control of gastric acid cid secretion with proton pump inhibitors.